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Selected Serotonin Reuptake Inhibitors and Treatment of Aggression
Intermittent explosive disorder is common in adolescents and adults with FXS, as described in chapter 1. Episodic and unpredictable aggression was a common reason for institutionalization of men with FXS
in the past. Sometimes aggression can be treated successfully with a stimulant if ADHD symptoms are a component of the clinical picture (Bukstein and Kolko 1998). Clonidine can also be helpful in calming down hyperarousal to
sensory stimuli (Miller et al. 1999), which is a common problem in FXS and may be linked to aggression. If aggression is associated with an abnormal EEG that has spike-wave discharges, particularly in the temporal region, trial of
an anticonvulsant such as carbamazepine or valproic acid is appropriate, as previously discussed. Most commonly, however, aggression is associated with anxiety, which can be treated with a selective serotonin reuptake inhibitor
(SSRI) (fig. 8.3).
Selected Serotonin Reuptake Inhibitors and Treatment of Aggression: Continued
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This article is not intended to give medical advice for individual cases. Any change in medical treatment
should be done in consultation with appropriate medical personnel. This article is written for medical professionals. Some of the terms will be unfamiliar to those who are not trained in medical fields.
*This article is from the chapter on treatment in the 3rd edition of Fragile X Syndrome: Diagnosis, Treatment, and Research edited
by Randi Jenssen Hagerman, M.D. and Paul Hagerman, M.D., Ph.D., to be published May 2002. It is included with permission from The Johns Hopkins University Press. References to other chapters refer to chapters in
the book which are not included as part of this website.
The complete 3rd edition of Fragile X Syndrome: Diagnosis, Treatment, and Research can be ordered from the National Fragile X Foundation by calling
1-800-688-8765 or from The Johns Hopkins University Press at 1-800-537-5487.
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Medical Follow-up Pharmacotherapy Future Prospects
Outline Medications Medical Conditions
References: A, B, C, D, EF, G, H, IJ, K, L, M, NOP, QR, S, T, UVWXYZ
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